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Pierre Fabre S.A. Signs Provantis License Agreement

January 2005

Instem LSS is delighted to announce that Pierre Fabre S.A. of France has signed a Provantis license agreement for its Pharmacology & Toxicology laboratory based in Tours, France.

The agreement includes the core Provantis modules covering General Toxicology, Clinical Pathology and Pathology, to be implemented in Phase 1. In addition Pierre Fabre has also purchased the Dispense module for its formulation area and Instem's unique Toxicology Resource Planning tool "TRP" for implementation in Phase 2, later in 2005.

Pierre Fabre's Director of R&D IT, Thierry Adenis said, "We were looking to implement a new, modern Toxicology Data Management System to ensure that electronic collection and handling of in-house toxicology data would be fully GLP compliant and validated and would enable faster generation of study results" He also added "Pierre Fabre evaluated the alternative software products on the market and were particularly impressed with Instem's proven services capability and the breadth and depth of their software solution."

The Pierre Fabre and Instem teams will be working to an aggressive Implementation Plan and Pierre Fabre has purchased a range of on-site services, including Validation, Installation and Training, to ensure that Provantis is implemented in a timely and cost-effective manner.

Gregor Grant, VP Sales at Instem said, "We are delighted to welcome Pierre Fabre as our latest customer. This deal has once again underlined that Provantis continues to be the product of choice for the world's leading R& D facilities."

About Instem

Instem is a world-leading information solutions provider for the Life Sciences - accelerating drug and chemical development by increasing client productivity and enhancing the processes that lead to safer, more effective products.

Established in 1969, Instem has offices in the United States and Europe with its solutions supported in thirteen countries. Instem serves large multi-national corporations and smaller organizations in overcoming the challenges of managing information and provides solutions that help them further their missions while creating a competitive advantage. For more information on Instem and its solutions, please visit www.instem.com or contact them by email at info@instem.com.

About Pierre Fabre

The Pierre Fabre Group employs over 9,000 people and is present in the ethical drugs, family medication and dermo-cosmetic care sectors with brands such as Avène, Ducray, A-Derma, Galénic, Klorane and René Furterer. The Group generates 44% of its activity from international markets. With over 1000 researchers, Pierre Fabre Médicament dedicates 23 % of its sales to R&D, notably in five main therapeutic areas, decisive for public health: Cancer therapy, Central Nervous System, Cardiology, Internal Medicine/Urology and Dermatology.

Press Contact:

Gary E. Mitchell, VP Global Marketing, Instem US HQ
Tel: (610) 941-0990
Email: gary.mitchell@instem.com

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