Instem - Information Solutions For Life

Solutions

• Provantis
• Genetic Toxicology
• Submit SEND solution
• Toxicology Resource Planning
• Information Management
• Regulatory

Overview
Instem Pathology solution is based on the Provantis™ Pathology product. The Provantis™ Pathology product is a fully featured Microsoft Windows application for the collection, processing and reporting of data for gross and histopathology, including mass tracking and organ weights. In the collection of death details, the user can specify the removal reason and a terminal body weight. It provides a consistent, familiar look and feel, seamless access to your favorite Microsoft applications and powerful, flexible reporting.

Data Collection
Data collection is fast, accurate and flexible. As well as offering a choice of keyboard entry, using user defined codes, or mouse entry picking from lists, there are a wide variety of user preferences to allow you to work in the way you choose – one animal at a time – by tissue - in a matrix of animals and tissues – the choice is yours. Sophisticated completion checking prevents errors and ensures protocol adherence.

Numerous shortcuts are available to the experienced user and keyboard/mouse activity has been ergonomically reduced to a minimum.

Integration
The pathology module is fully integrated with the rest of Provantis™, so it shares a common protocol and makes all the other data such as In-life data, necropsy, organ weights and clinical pathology data available to the pathologist.

Reporting
A large selection of standard ready-to-publish reports are available. These feature multiple selection criteria, including page headings, animal/group selection and the option to include full or partial observation detail (eg tissues, morphology, modifier):-

Summary reports - Intergroup comparison of gross/histo observations, Intergroup comparison of organ weights and organ weight ratios, Gross/Histopathology observations - animal cross-reference, Tumor summary, Combination incidence of tumors, Chronological listing of tumors, Completed animals, Cause of death summary, Incompleteness check, Major Pathological findings, FDA Biometrics report

Individual animal reports - Animal data, Gross pathology observations, Correlation of findings, Cause of death, Palpable mass diagnosis and Individual organ weights

An example of the flexibility can be seen in the intergroup comparison reports, where there is an option to show male/female-only data or combined. One of the reporting format options is to show animals by removal reason and group. Other options include animals with findings only and/or observations split by severity. For histo, the user is able to request neo and non-neoplastic observations separately or combined. Incidences can be shown as percentages or absolute. Syndromes and Merging and Include/Exclude facilities allow manipulation of the presentation of findings.

A number of animal history reports (including mass tracking from in-life, through gross to histo), raw data and glossary reports are also available.

Latest features
New functionality includes:-

• Advanced Matrix entry – allowing even faster data entry directly in the matrix
• Direct, automatic inclusion of pathology data into protocol and reports
• Enhanced Completion checking
• Simplified Glossary definition and maintenance
• Automatic production of histology labels from Protocol to Labeling module
• Remote Pathology allows offsite slide reading with full In-Life/Gross information