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Reproductive Toxicology

Overview
The Reproductive Toxicology product is a modern, flexible solution that supports the toxicologist and teratologist in the management, performance, analysis and reporting of all reproductive study types, including:

  • ICH study types (fertility and embryo-foetal development, pre- and post-natal development and embryo-foetal development)
  • Multi-generation
  • Developmental toxicity
  • Behavioral
  • Developmental neurotoxicity

Protocol
The reproductive toxicology module is fully protocol driven. The protocol recognizes the complex, phased nature of many reproductive studies and allows activities to be scheduled relative to study, pairing, mating and littering days, generational phases and observed events or measurements. This allows technicians to easily see what activities are due on which animals. The data entry programs prompt them in accordance with this schedule.

Data Collection
The full range of data collection functions are available, including:

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  • Oestrous cycle assessment
  • Caesarean section
  • Sperm analysis
  • Fetal pathology
  • Pairing
  • Blind reading within fetal pathology
  • Evidence of mating
  • Supervisor review of fetal findings
  • Parturition
  • Development signs
  • Fate allocation
  • Assignment to next generation

In addition the entire general toxicology data collection functions are provided for parental animals, litters and unidentified and identified pups.

Reporting
Reproductive toxicology data can be tabulated and analyzed in many formats, including:

  • Individual animal data tables
  • Group summary including various statistical analyses
  • Reporting by phase
  • Analysis of reproductive end-points
  • Calculation of numerous indices (e.g. fertility, survival, reproductive performance, observation indices by litter and foetus)
  • Analysis of pup data
  • Raw data and audit reports

Latest features

  • Blind Reading in Fetal Pathology
  • Supervisor Review for Fetal Pathology Findings
  • Staggered Delivery Randomization
  • Label Creation & Printing, including reproductive toxicology information
  • New Reproductive Tables
    • Intergroup Comparisons:
      • Pup Mortality
      • Pup Bodyweights
      • Pup Bodyweights Gains
      • Litter Weights
      • Litter Weights Gains
      • Pup Developmental Markers – By Day Summary
      • Pup Developmental Markers – Cumulative Count
    • Delivery Data:
      • General Details
      • Mean Pup Counts Changes to Existing Tables
    • New Analysis Periods
      • Weight Gain Tables allow the definition of weight gain intervals
      • Pup Tables allow multiple analysis periods
    • Better Account of Reproductive Phases
    • Descriptive Statistics
      • Mean
      • Standard Deviation
      • Maximum Contributory Value
      • Minimum Contributory Value
      • Standard Error (of Means)
      • N – number of contributory values
  • Reproductive Statistics
    • 1 way, 1 way mixed & 2 way ANOVA
    • Kruskal Wallace
    • Likelihood Ratio Chi-Square
    • Generalised Wilcoxon’s test for censored data